Recently, hepatic SEPP1 expression was shown to be controlled through coordination of the transcription factors FOXO1a and HNF-4α by the coactivator PGC-1α (Speckmann et al. 2008; Walter et al. 2008). Discovery of this mechanism introduces the idea that SEPP1 can be regulated in response to hormonal stimuli and may be responsive to various nuclear receptors due to the versatility of PGC-1α.
