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Chunk #3 — Evaluating the Weight of Evidence for AUD Candidate Endophenotypes — Neurophysiology

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Endophenotypes for Alcohol Use Disorder: An Update on the Field.
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Numerous dimensions of resting and event-related EEG measures (e.g., alpha, theta, and beta oscillations) broadly index information processing and cognitive functioning. Neurophysiological measures are highly heritable [20], and individuals affected with AUD and individuals at high-risk for AUD (offspring of male alcoholics) have elevated resting high-frequency (beta; 12–28 Hz) brain oscillations [21] compared to unaffected and low-risk individuals.