8). On the other hand, the complement system has been implicated in synaptic plasticity (Stephan et al., 2012), and some of the changes observed in the immune process and inflammatory response may result in positive alterations in synaptic function. The results with WGCNA (Table 5, Yellow module) support the contention that positive alterations in synaptic function may have occurred under the excessive binge-like drinking conditions utilized in the present study. However, with few exceptions, the individual genes in this module were not significantly different at a modest p value of .01.
