have to retain any biases (though again it is still possible for bias to arise44); one important aspect of study design will be the method of sub-selection of Biobank subjects to feed into an analysis. In the case of focused hypothesis testing, it is likely that carefully selected sub-groups of subjects should be utilized. For example, once a group of subjects is identified with a clinical diagnosis, it is likely that optimal sensitivity and interpretability will require a control sub-group that is matched over many relevant factors (e.g. sex, age, relevant life factors not appearing in the predictive model).
