effects of ethanol, showing that brain synthesis of neuroactive steroids can modulate effects of ethanol (Khisti et al. 2003). However, neuroactive steroids do not appear to influence the motor incoordinating effects of ethanol, since neither finasteride administration nor adrenalectomy diminish these actions (Khisti et al. 2004). Taken together, these studies suggest that elevations in neuroactive steroids influence many of the GABAergic effects of ethanol in vivo and contribute to sensitivity to the behavioral effects of ethanol.
