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Chunk #4 — Methods — Study Population

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C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.
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nonfatal myocardial infarction (MI) or fatal coronary heart disease (CHD) over 8 years of follow-up. In the HPFS, we similarly identified 266 men with incident nonfatal MI or fatal CHD over 6 years of follow-up. Using risk-set sampling which selects controls from the base population that gave rise to the cases,[27] controls were randomly selected 2:1 matched on age, smoking, date of blood draw, and fasting status (women only) from participants free of cardiovascular disease at the time the case was diagnosed.