nonfatal myocardial infarction (MI) or fatal coronary heart disease (CHD) over 8 years of follow-up. In the HPFS, we similarly identified 266 men with incident nonfatal MI or fatal CHD over 6 years of follow-up. Using risk-set sampling which selects controls from the base population that gave rise to the cases,[27] controls were randomly selected 2:1 matched on age, smoking, date of blood draw, and fasting status (women only) from participants free of cardiovascular disease at the time the case was diagnosed.