A further important issue emerging out of this review is that few studies have investigated the effects of chronic cannabis use on the brain in adolescence subjects. In light of the popularity of cannabis among teenagers [1], [2] and recent data showing the potential neurotoxic effects of chronic cannabis use on the maturational brain [188], investigation of the possible long-term effects on brain structure and function in the adolescent population should be a priority both from the scientific and population health perspective [34], [188]. Future studies should consider the need for convergent methodology, replication of known facts with greater methodological rigor, and prospective large samples involving subjects of both genders across the life-span from adolescence to adulthood to delineate the evolution and reversibility of previously reported alterations.
