For comparison against more standard (stratified) analysis strategies, all analyses were also run stratified by self-identified race/ethnicity. A minor allele count of at least five was required for a stratified model to be run within an ethnic group. The stratified analyses were then meta-analysed using a fixed-effect model implemented in METAL43. I2 and χ2 heterogeneity P values were estimated for all meta-analysed results and represent effect size heterogeneity driven by self-identified race/ethnicity. The race/ethnicity-specific results, I2 and χ2 heterogeneity P values for all novel and secondary findings are included in Supplementary Table 3.
