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Chunk #20 — Methods — Multivariate GWAS

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Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk.
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Clumping was performed in Functional Mapping and Annotation of Genome-Wide Association Studies (FUMA) version 1.6.150 using an r2 threshold of ≥ 0.6 to define independent significant SNPs, a second threshold of r2 ≥ 0.1 to define lead SNPs, and a maximum distance between LD blocks of 250kb to merge into a locus.