The Collaborative Study on the Genetics of Alcoholism (COGA) previously reported an association with genome wide significance between the power of theta band (4–7 Hz) EROs in a visual oddball task and KCNJ6 single nucleotide polymorphisms (SNPs) in a predominantly adult sample (Kang et al., 2012). The protein encoded by KCNJ6 is known as GIRK2, which is widely distributed in the brain and is an important functional element in dopaminergic, cholinergic, GABAergic and glutamatergic synapses and hence regulation of neuronal excitability (Saenz del Burgo et al., 2008). To examine the age variation in the association between theta EROs and KCNJ6 SNPs during adolescence and young adulthood, the current study followed the methodology of a recent study of developmental trajectories of theta EROs (Chorlian et al., 2015), using the same sample of adolescents and young adults. Consideration of the results in that study (Chorlian et al., 2015), as described in section 3.1, informed the analysis employed in the present study. The developmental trajectories (time-series) of the association between KCNJ6 gene variants and theta band EROs during the P3 response to targets
