Chunk #9 — Materials and Methods — Nicotine dependence GWAS meta-analysis and independent follow-up

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Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

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Regional association plots were created using LocusZoom33 with linkage disequilibrium (LD) estimates of r2 and D’ based on 1000G EUR and AFR panels. Allele frequencies were weighted by sample size. Odds ratio (OR) estimates were computed using the β estimate from the SNP term in the linear regression model (e[2×β] for severe vs mild dependence) and then compared across studies using the Forest Plot Viewer.34 Heterogeneity across studies was assessed using the I2 index.35