In this paper, the majority of our previously reported alcohol response findings across a variety of subjective and objective measures in HD were replicated in an independent second sample. Of the fourteen measures being reported, we were able to fully replicate the results of eleven, including all four subjective effects, cortisol response, and performance impairment measures. These findings confirm that in response to an intoxicating dose of alcohol, HD report escalations in the stimulating and hedonically rewarding effects during rising and at peak BrAC, with increases in sedative effects primarily during declining BrAC. Furthermore, HD are acutely impaired by alcohol on most measures of psychomotor and eye tracking performance at peak BrAC without displaying a discernible cortisol response at any point. As a whole, this acute alcohol response phenotype in HD appears to be robust and reproducible.
