Chunk #7 — Metabolism and Epigenetics — DNA Methylation
Text
Altered methionine metabolism and the subsequent hypomethylation is one mechanism by which alcohol produces alcoholic liver disease and HCC (Medici and Halsted 2013). In addition, alcohol-induced degradation of DNMTs and hypomethylation supports a potential epigenetic mechanism for FASD (Chen et al. 2013; Mukhopadhyay et al. 2013).