There are a number of limitations that should be considered when evaluating our findings. The lack of association observed regarding some SNPs, inhibitory control and negative-reward sensitivity could be related to the study’s design. The small sample size may have limited our ability to detect genetic effects in subgroups based on dependence diagnoses. For example, few cannabis-dependent individuals carried the A allele of the DRD2 rs6277, so it was not possible to explore behavioral traits in relation to this SNP. Another factor to consider is the cross-sectional approach of this study. The acute neurocognitive effects of cannabis might have affected task performance. While subjects had at least 2 hours of observed abstinence before performing the tasks, we cannot exclude the contribution of such confounding factors and our results should be replicated in settings where chronology of recent use may be better monitored. The fact that our sample was drawn from a population without significant psychiatric comorbidity also opens up the question as to whether these results may be generalizable to other comorbid subgroups. Replication of our results in a larger
