Systemic injection of OXT has been demonstrated to dose-dependently reduce cocaine self-administration using operant conditions procedures across varying schedules of reinforcement in male (Zhou et al., 2014) and female (Leong et al., 2016) rats. Additionally, using a model of behavioral economics, Bentzley et al., (2014) demonstrated that OXT administration reduced the demand and suppressed motivation for cocaine in male rats with a history of cocaine self-administration. Systemic OXT administration (0.3 and 1mg/kg; ip.) reduced active lever responding and methamphetamine infusions using operant self-administration procedures and reduced motivation to respond for meth on a progressive ratio schedule (Carson et al., 2010a, Carson et al., 2010b). Additionally, central administration (icv) infusions of oxytocin (2.5ug) impaired the acquisition of methamphetamine-induced conditioned-place preference (Qi et al., 2009). However, infusion of OXT during training, rather than pretreatment before testing, had no effect on meth place preference (Qi et al., 2009).
