Despite the controversies regarding when and whether to obtain pharmacogenomic testing, the improvements in technology supporting these tests, improved accessibility of testing options, and the growing number of resources that help clinicians understand how to use this information when it is available are making this aspect of personalized or precision medicine a reality. Thus, it is important for providers to become more aware of the science and clinical relevance of pharmacogenomic tests. Additionally, multiple options exist that may be used for testing, not all tests interrogate the same genetic variants, and some of these differences may have important clinical consequences. Continuing the education of established providers as well as clinical trainees is an important step in this process, which will continuously evolve as technology and clinical evidence informing testing and application are advanced.