To help expedite the process, the F-SNP database aims to provide a comprehensive collection of functional information about SNPs, using a large variety of publicly available tools and resources. Specifically, it provides information about potential deleterious effects of SNPs with respect to four major biomolecular functional categories, namely, splicing, transcription, translation and post-translation. Moreover, for assessing the deleterious effect of SNPs along each functional category, F-SNP integrates multiple tools that are based on different algorithms, data and resources. No single tool can yet capture all the possible effects of SNPs on even one biological function (2). Providing predictions from multiple diverse methods thus helps to better assess the functional impact of each SNP. Researchers can also use the raw predictions provided by F-SNP to implement their own tool for evaluating functional effects of SNPs.
