paperKB
coga / coga-kb
Help
Sign in

Chunk #10 — Results — Biological convergence of cis- and trans-eQTLs

Source
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
Embedded
yes

Text

While multiple associated SNPs have been identified for many complex diseases, it often remains unclear what the intermediate effects of these variants are that eventually lead to disease. It is reasonable to assume that for a particular phenotype the different associated SNPs eventually converge on the same downstream gene(s) or pathways.