susceptibility alleles, as part of a larger effort to interrogate the complex genetic architecture of ASDs. Because the genetic aetiologies of ASDs may be linked to the neurobiological components that build and modify connectivity of the brain, by comprehensively identifying the relevant genes, genomic variants and genetic pathways, more focused analysis on gene expression, as well as structural and functional imaging, can be performed on subjects carrying specific genetic defects. Together with studies addressing epigenetic modifications and comprehensive analysis of environmental risk factors, these pieces of information can be better integrated to improve our understanding of the molecular basis of ASDs, and foster the development of early preventive and corrective strategies.
