At doses similar to the dose that we used, Asakawa et al. (2003) and Beck et al. (2004) reported decreased food intake in rodents after systemic treatment for up to 24 h post-administration. Asakawa et al. (2003) also observed that D-Lys3-GHRP-6 had similar effects on food intake when administered systemically and intracerebroventricularly, which shows that the drug crosses the blood brain barrier.