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Chunk #4 — METHODS — D-Lys-3-GHRP-6

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Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons.
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At doses similar to the dose that we used, Asakawa et al. (2003) and Beck et al. (2004) reported decreased food intake in rodents after systemic treatment for up to 24 h post-administration. Asakawa et al. (2003) also observed that D-Lys3-GHRP-6 had similar effects on food intake when administered systemically and intracerebroventricularly, which shows that the drug crosses the blood brain barrier.