The STRUCTURE results (K = 2) from individuals with 4 grandparental data (not used for ESAIM selection) showed separation of most of the 220 self-identified individuals of Ashkenazi Jewish heritage (mean 83% south; median, 87%) from 37 individuals of Western, Northern or Central heritage belonging to the “northern” group (mean 4% south; median, 3%), and 51 individuals of Greek, Italian, or Spanish origin were intermediate (mean 41% south; median, 42%) (Figures 3 and S1). These 1441 north/south-ESAIM showed small confidence limits in the assignments; of the total of 677 individual individuals not used in ESAIM selection the maximum 90% Bayesian confidence interval (CI) was 21.1% (e.g. 13.7 % south, 90% CI 2.6 % – 23.0 %) and the median CI was 13.9%. Smaller north/south-ESAIM sets showed strong correlations with the 1441 set e.g. 384 ESAIMs (r2 = 0.970) (Figure S2). However, the smaller north/south-ESAIM sets showed somewhat broader confidence limits (e.g. 384 north/south ESAIM set showed maximum CI = 38.9% and a median CI = 17.1%. However, these differences are unlikely to affect most studies. The larger number of north/south-ESAIMs
