Gene-based association analysis was performed by integrating GWAS association statistics and eQTL data of all brain and whole-blood tissues from GTEx v8. To prioritize target genes further, joint effects of gene expression correlation across tissues was leveraged using S-MultiXcan.15 153 genes and their best representative tissues were below the Bonferroni corrected significance threshold (1.79×10−7) for predicted gene expression in 14 tissues (Figure 3 top; Supplementary file 2). Top genes for each tissue tested were: Amygdala (ZKSCAN4, p=1.65×10−12), anterior cingulate cortex (L3MBTL2, p=1.09×10−14), caudate (ZNF184, p=1.85×10−9), cerebellar hemisphere (PGBD1, p=1.67×10−13), cerebellum (ZSCAN9, p=8.4×10−17), cortex (TMEM161B, p=1.84×10−12), frontal cortex (FAM120A, p=3.25×10−10), hippocampus (ZSCAN12, p=1.14×10−18), hypothalamus (NEGR1, p=3.19×10−25), nucleus accumbens (DRD2, p=1.87×10−20), putamen (LIN28B-AS1, p=2.13×10−12), spinal cord c-1 (HIST1H1B, p=2.90×10−18), substantia nigra (RP11–318C24.2, p=2.41×10−12), and whole blood (ZNF165, p=4.01×10−11).
