We have uncovered a new locus for VAT at THNSL2 in women that reveals a striking sexual dimorphism, where we observed significance only in women, but not men. We also observed genome-wide significance for rs11118316 at LYPLAL1 for the VAT/SAT ratio; this region was previously identified in a GWAS for WHR in the GIANT consortium, although our lead SNP is only in moderate LD with the SNP identified by GIANT. Finally, we performed targeted SNP evaluations of 14 SNPs previously identified in association with central fat distribution and identified nominal associations at 7 loci.
