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Chunk #248 — IX. Classes of genes that are identified in multiple GWA samples for multiple phenotypes: focus on “druggable” targets

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
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The genes discussed here provide examples of potential therapeutic targets; many of the other genes identified by these studies may also provide equally tractable drug target sites. Indeed, some of the genes that are identified in genome wide data from only one or two phenotypes might conceivably provide targets for drugs with more favorable specificities and therapeutic indices than genes identified by GWA data for many phenotypes.