expresses GluA1 subunits but not CNIH-2? Our results would suggest not, since the surface expression of GluA1 in neurons requires CNIH-2. Also of interest are Purkinje neurons, which express high levels of CNIH-2, but only transiently express GluA1 (Douyard et al., 2007). It is also worth noting that additional AMPAR auxiliary proteins have been identified, such as CKamp44, which is expressed in DG but not CA1 pyramidal neurons (von Engelhardt et al., 2010). Whether a functional relationship between CKamp44 and CNIH proteins exists in DG remains to be determined. Another interesting question is whether the ability of CNIH proteins to influence AMPAR gating is utilized in other types of neurons.
