The fourth aim is related to data sharing. Consistent with the goal of rapid progress, we have been communicating pre-publication results widely. Where informed consent and Ethical Committee rulings allow, de-identified phenotype, genotype, and mega-analysis results will be deposited into controlled-access repositories (e.g., dbGaP, NCBI database of Genotypes and Phenotypes) (Mailman et al. 2007) in order to make these data available for future use by the international scientific community.