captured with the same library used for the TIC Genetics cohort and sequenced using Illumina technology. 311 TD trios (311/325, 95.7%) and 602 SSC trios (602/625, 96.3%) passed quality control (Table 1; Table S1). We summarize sequencing metrics in Table 1 and detail all sample- and cohort-level data in Table S1. The distribution of de novo coding variants per individual in the TIC Genetics cohort and in the SSC siblings follow an expected Poisson distribution (Figure S1), as has been observed in other disorders (e.g., Fromer et al., 2014; Homsy et al., 2015; Neale et al., 2012; Sanders et al., 2012; Xu et al., 2012).
