DNA methylation in that region (PP3+PP4 > 0.99; Supplementary Table 17). Twenty-six of these pairs (covering 15 regions associated with schizophrenia) had a higher posterior probability for both schizophrenia and DNA methylation being associated with the same causal variant (PP4/PP3 > 1), with 16 (10 regions) of these having sufficient support for them to be considered as ‘convincing’ (PP4/PP3 > 5) according to the criteria of Giambartolomei and colleagues35. Of note, three of these top-ranked pairs are annotated to the AS3MT locus within a robust schizophrenia-associated region on chromosome 10 (Supplementary Table 17). The utility of mQTL mapping for localizing putative causal loci associated with disease within this region is shown in Fig. 3, with additional examples for other schizophrenia-associated regions available on our website (http://epigenetics.essex.ac.uk/mQTL/).
