Understanding the pathways by which our genes confer risk, and the limitations inherent in genetic liability scores, highlights why genetic information is not determinative. Gene-outcome associations are correlated with - and importantly, can be interrupted by - environmental processes. Mapping genetic pathways, understanding how associated genes lead to elevated risk, yields information about how to intervene. This information will be critical for precision medicine, so we can help individuals understand what it means to be at elevated genetic risk, and what they can do to reduce risk.
