associated with numerous psychiatric disorders that are commonly reported to co-occur with AUD. However, and importantly, we identified that the associations between Problems PRS and mental health did not persist in the absence of the clinical manifestation of AUD. These findings suggest that the associations with mental health are not the result of horizontal pleiotropy. Instead, they may be either (i) a consequence of AUD, (ii) correlated with other risk factors for AUD (along and/or aside from genetic risk), or (iii) related to ascertainment of patients with diagnosed AUD in the medical record. These results also encouragingly suggest that treating AUD could have widespread improvements in overall health.
