Chunk #24 — Results — Dynamic expression of Mecp2 isoforms during NSC differentiation and DNA methylation patterns at the Mecp2 regulatory elements

Source

Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells.

Embedded

yes

Text

MECP2 expression levels [2]. In mouse brain exposed to maternal separation and stress, DNA methylation changes that are as little as 2 to 5% at individual CpG sites of the Mecp2 promoter are associated with significantly reduced MeCP2 expression [20]. As even slightly altered MECP2/Mecp2 promoter methylation (2 to 5%) affects MECP/Mecp2 gene expression in the human and mouse brain, it is likely that the statistically significant changes detected in the present study might be biologically important for Mecp2e1 and/or Mecp2e2 expression.