study are likely markers of risk, rather than a consequence of heavy alcohol use. Interestingly, the influence of PRS on EEG connectivity differed among those with and without AUD (lifetime diagnosis), suggesting that the PRS has a greater influence on alpha EEG coherence throughout the brain at ages 18–24 in those with AUD, in contrast to a more limited influence on posterior alpha EEG coherence at ages 24–31 in those without AUD (Supplementary Figure S3). However, future work is needed to better understand these observed differences in the context of the many factors that differ between the two groups, including drinking behavior, mean level of DSM-IV AD PRS, psychosocial influences, etc.
