Due to the consistency of the association results with the same set of three SNPs, we constructed haplotypes using only SNPs rs4425326 and rs6857715 (r2=0.18); the high r2 (0.98) between SNPs rs4333136 and rs6857715 made use of both redundant. The global haplotype test and several individual haplotypes were significantly associated with alcohol dependence, alcohol dependence with severe withdrawal, alcohol dependence in the absence of cocaine dependence, comorbid alcohol and cocaine dependence, and cocaine dependence (all global haplotypes p<0.04; Table 3). For all five phenotypes, the most frequent haplotype, C-C, was overtransmitted to affected individuals. The complementary, second-most frequent haplotype, T-T, was overtransmitted to individuals who did not meet the criteria.
