We tested association between rs11174811 and two core COGA phenotypic measures, alcohol dependence and maximum drinks in a 24-hour period in the male European-American sample (n = 745). The SNP was modeled as the number of A alleles of the associated SNP using a linear model in PLINK (http://pngu.mgh.harvard.edu/∼purcell/plink/) (30) for the quantitative trait (maximum drinks per day).
