the difference from the mean at the 0 time point, particularly in the non-placebo sessions. Therefore, we summarized the six measurements for each phenotype in each session, for each individual, using two numbers: (i) the first time point (0 min), which we refer to as the baseline measure; and (ii) the mean of the last four time points (60, 90, 150, 180 min) controlling for the first time point (0 min), which we refer to as the response measure. Note that, by construction, these two summary values are uncorrelated.
