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Chunk #41 — Online Methods — Meta-analysis of genome-wide association study summary statistics

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
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conditional analysis 59 was used to identify independently-segregating variants in each of the merged loci that was genome-wide significant, using the linkage disequilibrium structure of UK Biobank as a reference panel. Genome-wide statistical significance was defined as P < 5 × 10-8, with the meta-analysis results from Metal reported. Due to the complexity of the major histocompatibility complex region only the most significant variant in that region is reported.