Chunk #29 — Results — I. Effect of 3-hour heroin self-administration, extinction, foot shock- and heroin-induced reinstatement — 2. Extinction

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Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats.

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Responding on the inactive lever during the four extinction sessions is represented in Fig. 2B. ANOVA revealed only a significant main effect of Session [F(3,103) = 4.88, p<0.005]. Newman-Keuls post hoc tests showed that the H-RI rats responded significantly more on the inactive lever in Session 1 than in Session 4 (p<0.005). Neither the L-RI nor the NR rats showed responding differences across Sessions. In Session 1, the H-RI rats showed significantly higher responding than the NR rats (p<0.05).