A whole-brain voxel-wise analysis of odor effects was first conducted to confirm mPFC and vmPFC ROI activation in response to [AcO > SO] and [AcO > AppCo]. This analysis indeed shows activation in the a priori ROIs, particularly in the mPFC (see Figure 3): Medial frontal response to alcohol aromas, regardless of the control condition, reaches cluster level significance, pFDR < 0.05, after correcting for false discovery rate (FDR) for the whole brain volume (voxel-wise height threshold, p < 0.001, see Table 2 for details). Both [AcO > AppCo] and [AcO > SO] contrasts elicited peak activity in the left vmPFC (Table 2) that extended dorsally into left mPFC and laterally into right vmPFC.
