Analysis of the control datasets split by platform demonstrated no artifactual “cross-platform” heritability (h2 = 0.000001; se = 0.11, p = 0.5) (Table S2). The overall narrow-sense heritability for TS calculated using the directly genotyped data of 617 TS cases and 4,116 controls was 0.58 (se = 0.09, p = 5.64e-12) and for OCD (1,061 cases, 4,236 controls) was 0.37(se = 0.07, p = 1.5e-07) ( Table 1 ). In order to test for possible inflation in the TS heritability point estimate due to small sample size, the OCD analysis was repeated using a random set of 617 OCD cases that matched the TS sample size. This experiment yielded a near-identical heritability point estimate for OCD with an expected increase in the standard error (h2 = 0.36; se = 0.12, p = 0.0009). For each primary analysis, ten permutations of the phenotype were conducted as an additional control, yielding on average no significant heritability (h2 TS = 0.06, se = 0.07, p = 0.3; h2 OCD = 0.06, se = 0.08, p = 0.3). Analyses were also conducted on imputed
