We performed fine mapping for TWAS in EUR using FOCUS, a method that models correlation among TWAS signals to assign a PIP for every gene in the risk region to explain the observed association signal. The estimated credible set containing the causal gene can be prioritized for functional assays. FOCUS used 1000 Genomes Project EUR samples as the LD reference and multiple expression quantitative trait loci reference panel weights. Under the model of PAU as substantially a brain disorder, we did fine mapping while prioritizing predictive models using a brain tissue-prioritized approach.
