Our findings expand the known genetic architecture of nicotine dependence, by showing that the DNMT3B SNP rs910083 increases the likelihood of developing nicotine dependence as observed across two different ancestries, smoking heavily, and consequently incurring a heightened risk of lung cancer.53, 55 The convergence of prior and current findings indicate that the complex neurobiology underlying nicotine dependence involves several sequence variants with functional and regulatory effects across distinct brain tissues.
