studies using synchronization measures recorded by MEG 18, 30 and intracranial EEG 34 have found similar results, suggesting PAC and phase synchronization may be more prominent in the left hemisphere of temporal areas during working memory tasks with complex objects. However, why such behaviorally significant lateralized effects exist remains a topic of open investigation 37, 38. Research employing neuromodulation techniques may be uniquely suited to help us better understand the contributions from each hemisphere. For example, it would be interesting to test whether theta-tuned HD-tACS can exert similar connectivity and behavioral benefits when targeting right lateralized regions, or whether only modulation of left frontotemporal cortex elicits working memory advantages.
