Using the same univariate GWAS summary statistics employed in the original application of GWIS, we used Genomic SEM to fit a structural multivariable regression model in which the genetic component of EA was simultaneously regressed onto the genetic components of schizophrenia and bipolar disorder. Results confirmed the findings by Nieuwboer et al. (2016);23 the conditional standardized association between schizophrenia and EA was small (bg = −.016, SE = .096, p = .867), whereas there was a strong conditional standardized association between bipolar disorder and EA (bg = .283, SE = .113, p = .012; Supplementary Figure 7).
