While adiponectin levels are highly heritable (30–70%) [10],[11],[12], several well-designed studies have shown variable association between common polymorphisms in the adiponectin gene (ADIPOQ), possibly due to small sample sizes and different panels of single nucleotide polymorphisms (SNPs), ethnicities and clinical outcomes [12],[13],[14]. This has lead some observers to call for a more complete and systematic characterization of the genetic determinants of adiponectin levels [12].
