It is necessary to note that there is a shortage of studies specially focused on the specificity of gene expression status and its dynamics throughout late childhood and adolescence that might be partly explained by an inaccessibility of the biological material for such research, namely brain tissue, from young individuals. Most of the research on the developmental dynamics of the transcriptome in the CNS have been carried out on the fetal brain. Only a few studies consider postnatal developmental stages (Colantuoni, et al., 2011; Kang, et al., 2011; Somel, et al., 2009; 2010), which provide data on general trends of transcriptional changes in the brain during its postnatal development. Taken together, the published evidence indicate that most of the spatio-temporal differences of gene expression in the brain, which are detectable before birth, subsequently decrease during postnatal development; the similarity of transcriptomes among the brain regions in contrast increases.
