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Chunk #4 — Introduction

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Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats.
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factors were found between the continuous-access and water-control groups, whereas no significant differences were observed in the Acb between the multiple scheduled-access and the water-control groups, when measured the day after the last drinking episode. McBride et al. (2010) reported significant changes in gene expression in the Acb-shell and central nucleus of the amygdala (CeA) of P rats after binge-like alcohol drinking (8 weeks of access to 15% and 30% ethanol in 3 1-hour daily scheduled-access sessions). Although there were some categories of biological processes in common between the two regions (e.g., synaptic transmission, neurite development), there were few genes in common between the two regions.