Chunk #127 — III. Selected Methodological Issues — D. Ethical issues in high density genotyping of individuals who are selected due to self-reported illegal behaviors

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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High density, individual genotyping of DNA from individuals who are addicted to illegal substances raises additional issues. Many of these individuals are likely to have experienced involvement in criminal activities that goes beyond use of illegal substances. Since the risks of high density individual genotyping in this population have not been as generally discussed elsewhere, we provide several lines of information that may inform thinking about thse special ethical issues.