Previous studies have identified sexually dimorphic gene expression in the developing and adult human brain12-14. Analysis of our dataset using a sliding window algorithm and t-test model (FDR<0.01 with >2-fold difference in log2-transformed signal intensity; Supplementary Information 6.6), identified 159 genes, including a number of previously reported and newly uncovered genes with male- or female-bias in expression located on the Y (13), X (9), and autosomal (137) chromosomes. A large fraction (76.7%) displayed male-biased expression (Fig. 2a; Supplementary Table 7). Notable spatial differences were observed, and more genes had sex-biased expression during prenatal development than during postnatal life, with the adult brain characterized by the lowest number.
