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Chunk #17 — Introduction — Procedure — Alcohol Administration

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A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study.
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Subjects rated subjective responses to the infusions on the “high” (operationally to subjects as, “up-stimulated, feeling good”) and “intoxicated” (“drunk, tipsy, inebriated”) items of a modified (oral) Subjective High Assessment Scale (SHAS; Schuckit et al., 2000). Before starting the infusion pump, subjects used a uniform baseline of zero, with ratings subsequently varying from the 0 baseline to a maximum of 100 (the most “high” or “intoxicated” ever). Ratings were obtained at baseline, after reaching the calculated BrAC target before functional imaging, between each functional scan, and once just after the last functional imaging scan.