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Chunk #97 — Methods — Online Catalog and SMR, COLOC, TWAS

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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.
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Supplementary Data 2 shows the list of GWA/GWAMA studies we considered in this analysis. We applied S-PrediXcan to these studies using the transcriptome models trained on GTEx studies for patched version 6. For simplicity, S-PrediXcan only considers those SNPs that have a matching set of alleles in the prediction model, and adjusts the dosages (2 dosage) if the alleles are swapped.